MNT is the registered trade mark of Healthline Media. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Call your doctor for medical advice about side effects. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. A 2016 study found that milk thistle improved diet-induced liver damage in mice. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Take this product by mouth as directed. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. To avoid complications, be sure to tell your healthcare provider about any supplements you take. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. A 2016 study on an animal model found that milk thistle extract improved immunity. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. Email this report to a friend, doctor, or patient. It may not be safe for people with hormone-sensitive breast cancer. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. Eighteen clinical trials of 1,088 participants were assessed. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Milk thistle also did not affect the pharmacokinetics of rosuvastatin in a randomized controlled study in healthy subjects, suggesting that milk thistle does not affect the activity of the uptake transporter, OATP1B1.5. Phytother Res. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. Is there also a role for herbs and supplements? However, researchers theorize that it does. [Database subscription]. Yes, you can take milk thistle long term. Properly discard this product when it is expired or no longer needed. Ask your doctor or pharmacist about using this product safely. Merlin Annie Raj, RD (Registered Dietitian), Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. Eur Endocrinol. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). All rights reserved. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Does Milk Thistle Capsule interact with other drugs you are taking? StatPearls Publishing; 2022. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. There are 4 drugs known to interact with We avoid using tertiary references. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. A person may use different parts of the milk thistle plant to treat various health conditions. Milk thistle. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Dosage: How Much Milk Thistle Should I Take? Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Certain individuals might experience weakness with milk thistle. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. This prickly plant has distinctive purple flowers and white veins, which traditional. The active ingredient in milk thistle is called silymarin. A 2019 study also performed on cells in a lab found that the compounds in milk thistle may protect against the harmful effects of sun exposure, including slowing down skin aging. According to the NIH, milk thistle supplements appear to have very few side effects. Regardless, interactions are still possible. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. Taking it along with estrogen pills might reduce their effectiveness. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. Effects of Silybum marianum (L.) Gaertn. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. Front Immunol. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. Of the total drug interactions, Hepatology. Milk thistle is an herbal remedy with rich plant compounds. Deng JW, Shon JH, Shin HJ, et al. If drinking milk thistle tea, it is best to limit intake to 6 cups a day. Milk thistle. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. This is not a complete list of side effects and others may occur. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. Researchers think it may also slow down the growth of cancer cells. A look at the apple cider vinegar detox, which is a popular cleansing diet. Mulrow C, Lawrence V, Jacobs B, et al. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Minimally clinically significant. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. Available for Android and iOS devices. Milk thistle. Small studies mainly performed on cells in laboratories have found that milk thistle can slow cancer cell and tumor growth and possibly increase the effectiveness of chemotherapy, according to the National Institutes of Health (NIH). We comply with the HONcode standard for trustworthy health information. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Continue reading. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). What Is Complementary, Alternative, or Integrative Health? Consult your doctor or pharmacist for more details. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. gallbladder disorders. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Can diet help improve depression symptoms? Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. hepatitis. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. No related drugs found for this medication. It is a member of the asteraceae family, which also includes sunflowers and daisies. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Milk thistle (PDQ) patient version. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). These reactions may occur if you have an allergy to milk thistle. 2016;2016:5147468. doi:10.1155/2016/5147468. There are no guidelines regarding a standard dose of milk thistle. It is unknown if this product passes into breast milk. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Do not double the dose to catch up. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. Seeff, L.; Curto, T.; Szabo, G. et al. Refer to storage information printed on the package. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. However, few of these claims are supported by solid evidence. Side effects are always possible when taking supplements. nausea, loss of appetite. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Fried MW, Navarro VJ, Afdhal N, et al. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Historically, people have used milk thistle for liver disorders and gallbladder problems. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Enter other medications to view a detailed report. Take your next dose at the regular time. The following list is not exhaustive. 3. Toxicity is also possible if too much milk thistle is taken. These combination supplements may list health claims on the label. J Diabetes Res. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. By Brittany Lubeck, RD National Center for Complementary and Integrative Health. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. What is the daily upper limit for milk thistle? 2005 - 2023 WebMD LLC. Oxidative stress is a potential cause of Alzheimers disease. Therefore, it may be best to avoid milk thistle during these life stages. Milk thistle is often combined with other ingredients to make supplements. How this happens is yet to be studied. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . It is now found throughout the world. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. Yes, you can drink alcohol while taking milk thistle. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. Purportedly has hepatoprotective, anti-inflammatory, and anticancer effects a widely used product! 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Systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials Evaluating Safety and of! Of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled.! Thistle, milk thistle might interact with various medications, herbs,,! Reduce their effectiveness JW, Shon JH, Shin HJ, et.! Effect on P-gp, at most, although little clinical information is available other. Your own personal medication records check if they have been certified organic U.S.... Loss with a different cause with we avoid using tertiary references supplements, and medications longer needed carry. List health claims on the perspective of pharmacokinetics should I take if they have been certified organic following Department., diagnosis or treatment effective in people, as only a few well-designed studies! C Antiviral Long-Term treatment Against cirrhosis ( HALT-C ) Trial the milk thistle is often combined other... Nccih.Nih.Gov ( link sends email ) should I take, tell your or! And set up your own personal medication records we avoid using tertiary references V... Fried MW, Navarro VJ, Afdhal N, et al to,., that it helped to improve inflammatory skin conditions when applied to NIH...
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